Antibody Engineering


Antibody Engineering

One of the greatest opportunities synthetic biology brings is the engineering of monoclonal antibodies to boost their binding affinity and specificity for target receptors or ligands. Currently, there are numerous examples in the clinic where optimization of the Fab (Fragment of antigen binding) domains via antibody engineering enabled development of therapeutic monoclonal antibodies with wide therapeutic windows. Fab domain sequences can be identified and modified to generate variant libraries and the resulting high affinity sequences can be used for therapeutic antibody development.